Focus: Palmitoyl Tripeptide-5

Boost collagen Palmitoyl Tripeptide-5 Peptide peptides signal peptides Smaller Pores SYN®-COLL TGF-B

What does palmitoyl tripeptide-5 do for skin?


Palmitoyl Tripeptide-5 is a synthetic peptide comprised of the amino acids Lysine and Valine linked with a fatty acid derived from sustainable palm. Topically, it improves skin firmness and elasticity by encouraging collagen synthesis. A signal peptide, it increases TGF-β (Transforming Growth Factor-Beta) activity by mimicking thrombospondin-1 (TSP-1), a matricellular protein. Also known SYN®-COLL (patented by DSM Nutritional Products, LLC) or Pal-KVK, it helps to protect collagen and elastin by slowing degradation.


TGF-B Pathway - A key target in peptide science

Skin Benefits:

  • Firms:
    • 7% firmer skin by stimulating collagen synthesis, type I and II, when applied twice daily at 2.5% concentration within 84 days.
    • In vitro study of human fibroblast cultures treated with the novel tripeptide showed an increase in collagen synthesis of 119%, compared with cultures treated with standard TGF-β.
  • Smooths:
    • 12% reduction of wrinkles/fine lines when applied twice daily at 2.5% concentration within 84 days.
    • 350% more effective at reducing the appearance of wrinkles than a placebo. 
    • 60% of the participants observed reduced pore size, after 4 weeks of applying 2.5%, twice daily.
  • Protects:
    • Promotes healthy collagen and elastin by inhibiting matrix metalloproteinases (MMP1 and MMP3), the enzymes responsible for triggering degradation, inflammation and visible signs of aging.
    • In vitro study of human dermal fibroblasts treated with the novel tripeptide showed a 49% increase of hyaluronan, an ECM (extracellular matrix) component responsible for hydration, nutrient exchange, and free radical protection.


  • Effective in topical applications ranging between 1-3%. Results are dose-dependent.
  • Sensitive to acidic or alkaline environments lower than 5 pH or greater than 7 pH. For best results, wait 20-30 minutes before applying additional skincare.
  • Visible skin improvements observed within as little as 15 minutes from initial application, peaking at three months.
  • Well tolerated by all skin types – sensitive, rosacea-prone, and acne-prone.


  • Synthetic 


Palmitoyl Tripeptide-5: Clinical Study




  • Frontiers in Chemistry, 2020 Oct 30, 8: 572923, Cosmeceutical Peptides in the Framework of Sustainable Wellness Economy.
  • Cytokine Growth factor Reviews, 2000 (11): 59–69, Activation of latent TGF-beta by thrombospondin-1: Mechanisms and physiology.
  • Cell Journal, 1998 Jun; 93 (7): 1159-1170, Thrombospondin-1 is a major activator of TGF-beta1 in vivo.
  • Journal of Clinical, Cosmetic and Investigational Dermatology, 2016; 9:411-419, Skin rejuvenation using cosmetic products containing growth factors, cytokines, and matrikines: a review of the literature.
  • Applied Microbiology and Biotechnology, 2015, 99(21): 8847–8855, Short antimicrobial peptides as cosmetic ingredients to deter dermatological pathogens.
  • International Journal of Cosmetic Science, 2009 Oct; 31(5): 327–345 Role of topical peptides in preventing or treating aged skin.
  • Biotopix, Life Science Investments, Product Monograph.
  • The Journal of Clinical and Aesthetic Dermatology, 2009 Mar; 2 (3): 38-43, Immediate and Long-term Clinical Benefits of a Topical Treatment for Facial Lines and Wrinkles.
  • Household and Personal Care, Today, 2015 Nov: 10: 6-11, Activation of tgf a gateway to skin rejuvenation small synthetic-peptide mimics natural protein activity in skin to unlock tgf potential.

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  • Michelle Bequette on

    Thanks for taking the quiz, Jackee. The results only narrow down your best prospects based on your skin type and needs. Sending you an email with additional questions.

  • Jackee B on

    My results for the quiz came back with 10 products. Do I need all of them?

  • HyramT on

    kudos! heaps more helpful than another video of another teen applying a serum with a smile.

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