Palmitoyl Tripeptide-5 is a synthetic peptide comprised of the amino acids Lysine and Valine linked with a fatty acid derived from sustainable palm. Topically, it improves skin firmness and elasticity by encouraging collagen synthesis. A signal peptide, it increases TGF-β (Transforming Growth Factor-Beta) activity by mimicking thrombospondin-1 (TSP-1), a matricellular protein. Also known SYN®-COLL (patented by DSM Nutritional Products, LLC) or Pal-KVK, it helps to protect collagen and elastin by slowing degradation.
- 7% firmer skin by stimulating collagen synthesis, type I and II, when applied twice daily at 2.5% concentration within 84 days.
- In vitro study of human fibroblast cultures treated with the novel tripeptide showed an increase in collagen synthesis of 119%, compared with cultures treated with standard TGF-β.
- 12% reduction of wrinkles/fine lines when applied twice daily at 2.5% concentration within 84 days.
- 350% more effective at reducing the appearance of wrinkles than a placebo.
- 60% of the participants observed reduced pore size, after 4 weeks of applying 2.5%, twice daily.
- Promotes healthy collagen and elastin by inhibiting matrix metalloproteinases (MMP1 and MMP3), the enzymes responsible for triggering degradation, inflammation and visible signs of aging.
- In vitro study of human dermal fibroblasts treated with the novel tripeptide showed a 49% increase of hyaluronan, an ECM (extracellular matrix) component responsible for hydration, nutrient exchange, and free radical protection.
- Effective in topical applications ranging between 1-3%. Results are dose-dependent.
- Sensitive to acidic or alkaline environments lower than 5 pH or greater than 7 pH. For best results, wait 20-30 minutes before applying additional skincare.
- Visible skin improvements observed within as little as 15 minutes from initial application, peaking at three months.
- Well tolerated by all skin types – sensitive, rosacea-prone, and acne-prone.
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