Focus: Matrixyl (3000 & synthe'6)

ageless skin anti-inflammatory antiaging Boost collagen Boost Hyaluronic Acid matrixyl matrixyl 3000 matrixyl synthe'6 signal peptides

Matrixyl Skin Benefits

Matrixyl®, a trademark of Sederma, represents a range of synthetic, signaling peptides that boosts the skin’s production of collagen, the protein responsible for providing strength and structure. Signaling peptides, or Matrikines, are chemical messengers instructing the cell to perform a specific function, stimulating the skin’s natural process. Derived from the amino acids paired with a fatty acid Palmitic Acid, each form of Matrixyl® delivers distinct benefits, in addition to accelerating collagen production. 

  • Matrixyl® 3000
    • Palmitoyl Tripeptide-1 (original Matrixyl®) stimulates collagen and gylcosaminoglycans synthesis, for firmer and smoother skin. Also known as Palmitoyl Oligopeptide or Pal-GHK, the tripeptide is comprised of the amino acids glycine, histidine and lysine.
    • Palmitoyl Tetrapeptide-7, inhibits the inflammatory response with the suppression of interleukins (IL-6). Defends collagen degradation from internal and external stressors – UVA/UVB light, pollution, and diet - for firmer and more resilient skin. Also known as Pal-GQPR or formerly Palmitoyl Tetrapeptide-3, the tetrapeptide is comprised of the amino acids glycine, glutamine, proline, and arginine.
  • Matrixyl® synthe’6®
    • Palmitoyl Tripeptide-38 penetrates deep into the dermis to boost the production of collagen and the synthesis of hyaluronic acid, for firmer more radiant skin. Also known as Palmitoyl-Lysyl-Dioxymethiony-Lysine, the tripeptide is comprised of the amino acids lysine and methionine.

Skin Benefits:

  • Matrixyl® 3000
    • Lifts: Encourages gylcosaminoglycans (GAGs) synthesis, which fills the space between collagen and elastin within the dermis, improving sagging by 16.2% and elasticity by 5.5%.
    • Firms: Stimulates collagen synthesis (type I, IV, VII, XVII) reducing surface area of deep wrinkles by 39.4%, wrinkle density by 32.9%, and wrinkle depth by 19.9%.
    • Brightens: Improves skin roughness by 16% and skin tone by 15.5%.
    • Anti-Inflammatory: Inhibits inflammatory response and defends collagen degradation from internal and external stressors – UVA/UVB light, pollution, and glycation – delaying visible signs of damage by 5.5 years.
  • Matrixyl® synthe’6®
    • Firms: Stimulates collagen synthesis of type by 105%, type III by 104% and type IV by 42% when applied twice daily at 2% concentrations for 60 days – decreasing wrinkle volume by 31% of the forehead and wrinkle surface by 28.5% of the eyes.
    • Lifts: Diminishes sagging by 28% when applied twice daily at 2% concentration within 60 days.   
    • Plumps: Boosts Hyaluronic Acid synthesis up to 174%, improving skin hydration, elasticity and moisture.
    • Smooths: Improves Laminin-5 production by 75%, an adhesion glycoprotein that helps to anchor the epidermis to the dermis.
    • Repairs: Increases Fibronectin A levels accelerating repair within the Extra Cellular Matrix (ECM).


  • Effective in topical applications ranging between 3-10% for Matrixyl® 3000 and 2-4% for Matrixyl® synthe’6®.
  • Sensitive to light and heat degradation, choose airless/opaque containers and store in a dark place.
  • Peptides are sensitive to enzymes and acidic environments (lower than 4 pH). For best results, wait 20 minutes before applying Alpha Hydroxy Acid, Beta Hydroxy Acid, or Ascorbic Acid skincare.
  • Well tolerated by all skin types – sensitive, rosacea-prone, and acne-prone.


  • Synthetic 


Which Matrixyl does your skin need? What are Matrikines?Palmitoyl Tripeptide-5?



  • Critical Reviews in Oncology and Hematology, 2004 Mar, 49(3): 199-202, An introduction to matrikines: extracellular matrix-derived peptides which regulate cell activity. Implication in tumor invasion.
  • International Journal of Cosmetic Science, 2000 Jun; 22(3): 207-218, Biologically active peptides: from a laboratory bench curiosity to a functional skin care product.
  • Biomolecules & Therapeutics, 2014 Jul; 22(4): 321-327, Dermal Stability and In Vitro Skin Permeation of Collagen Pentapeptides (KTTKS and palmitoyl-KTTKS)
  • Indian Journal of Dermatology, Venereology, and Leprology, 2017 Jan-Feb; 83(1): 9-18, Topical Peptides as Cosmeceuticals.
  • Journal of Cosmetics, 2015 Jun: 14(2): 152-160, Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications.
  • International Journal of Cosmetic Science, 2009 Oct; 31(5): 327-345, Role of topical peptides in preventing or treating aged skin.
  • Clinical, Cosmetic and Investigational Dermatology, 2016 Nov; 9: 411-419, Skin rejuvenation using cosmetic products containing growth factors, cytokines, and matrikines: a review of the literature.
  • Molecular Pharmaceutics, 2013 Jan; 10(3): 1063-1069, Collagen Stimulating Effect of Peptide Amphiphile C16–KTTKS on Human Fibroblasts.
  • Sederma. Matrixyl synthe’ 6. Sederma, Inc. Claim Substantiation Sheet, 2010.
  • Journal of The European Academy of Dermatology and Venereology, 2005, 19:308-318, Hyaluronic acid: a unique topical vehicle for the localized delivery of drugs to the skin.
  • The Journal of Biological Chemistry, 2009 Jul 18, 284:25879-25888, Fibronectin Binds and Enhances the Activity of Bone Morphogenetic Protein 1.
  • Journal of Cell Science, 2002, 115:3861-3863, Fibronectin at a glance.
  • The Journal of Clinical Investigation, 2000 Jun 1, 105:1507-1509, Fibronectin peptides in cell migration and wound repair.
  • Journal of Cell Science, 1996, 109:2509-2520, Laminin-5 and hemidesmosomes: role of the alpha 3 chain subunit in hemidesmosome stability and assembly.
  • The Journal of Biological Chemistry, 1995, 270:23496-23503, The Assembly of Laminin-5 Subunits.
  • Journal of Cell Science, 2004, 117:1351-1363, Laminin 5 deposition regulates keratinocyte polarization and persistent migration.
  • Biochimica et Biophysica Acta – Biomembranes, 2015 Mar, 1848(3):833-841, Control and role of pH in peptide–lipid interactions in oriented membrane samples.

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    @Cheri: Thanks for the kind words and feedback. Happy to swap the dropper for a pump with your next order. Just leave a note or email me directly.

  • Cheri Carter on

    huge difference in wrinkles with reform, so it’s really working. prefer using a pump instead of the dropper for convenience.

  • Michelle Bequette on

    @Kellee: Thrilled that you are loving rePhorm, Kellee! Emailing you a discount code for c+therapy. :-)

  • Kellee Mendez on

    happy af with reform. you were 100, don’t need my eye serum. buying c serum next flex day. your legit!

  • LilleB on

    ADORE rePhorm with my clarisonic and the massaging attachment! My skin looks and feels better!

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