Hyaluronic Acid (HA) is a naturally occurring glycosaminoglycan (GAG) integral to healthy mammalian connective, epithelial, neural, and corneal tissues. It serves as an antioxidant, humectant, injectable, and dietary supplements within Medicine, Nutraceuticals, cosmetics, and skincare. Animals and humans synthesize it naturally, however our bodies metabolize it in less than a day and synthesis declines with age. By age of 70 years, the Hyaluronic Acid concentration found within skin tissue declines by 75%.
Applied topically, Hyaluronic Acid improves skin’s ability to retain moisture, hydration and elasticity through humectant properties, antioxidant protection, repair and re-generation. Saturating the skin with anti-aging, hydration, anti-inflammatory and healing capabilities, it is an effective choice for most skin types. Reactive and sensitive skin may respond better to high molecular weight (500k daltons or higher) HA.
- Hydrates: Helps the epidermis (outer skin layer) to hold moisture – up to 1000 times its own weight. Improves skin hydration up to 96% in 8 weeks.
- Firms: Improves firmness/elasticity by 55% in 8 weeks.
- Smooths: Reduces wrinkle depth by 40% in 8 weeks.
- Anti-Inflammatory: High-Weight HA (500K – 4M Daltons), calms, soothes, and promotes healing by reinforcing the skin’s protective barrier function.
- Protects: Antioxidant properties and ability to stimulate ceramide synthesis, mitigate environmental aggressors.
- Effective in topical applications ranging between 0.01- 2% concentrations.
- Sensitive to light degradation, so choose airless/opaque containers and store in a dark place. Do not refrigerate.
- Concentrations of 1% or greater affect tactile properties of topical formulations – feels sticky or tacky.
- Molecular weight varies widely, as do the skin benefits:
- High Molecular Weight (HMW) HA, ranging from 500k to 4M daltons, improves surface hydration.
- Low Molecular Weight (LMW) HA, less than 500k daltons, provides superior antioxidant, reparative, and anti-aging skin benefits, while enhancing enhancing the permeability of other water-soluble actives. May also trigger the skin’s pro-inflammatory response.
- Works nicely with most ingredients found in skincare. For extremely dry or compromised skin in low humidity climates, consider layering highly concentrated hyaluronic skincare with an essence and facial oil. This will will inhibit powerful humectant from drawing moisture from the deeper tissue layers of the skin.
- Synthetic (Biofermentation)
- Rooster Combs
- Bovine synovial fluid (Eye)
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Will keep coming back for more Rephyll! Props Michelle, for keeping it real.